Safety & Contraindications 

(EBOO & Ozone Therapy)

Last Updated: February 5th, 2026.

Important: EBOO and ozone-based therapies are offered as supportive wellness services and are not a substitute for emergency care or treatment from your primary medical team.

Who should NOT do systemic ozone therapy
(commonly listed as an absolute contraindication)

• Known significant G6PD deficiency (favism) due to risk of hemolysis with oxidative stress.¹

Who may need extra caution or medical clearance
(relative contraindications)

Depending on modality and clinical context, additional screening/clearance may be appropriate for individuals with:

• Bleeding disorders / blood coagulation failure or active bleeding risk¹

• Thrombocytopenia¹

• Recent myocardial infarction¹

• Hemorrhagic stroke / major recent cerebrovascular events¹

• Uncontrolled hyperthyroidism¹

• Pregnancy (especially first trimester) / medical-legal considerations¹

• Alcohol intoxication¹

Route and safety notes

• Safety depends on route, dose, and protocol. Some routes carry different risk profiles and should be selected clinically.²

• Inhalation of ozone is not used therapeutically and can be harmful to the respiratory system.²

• Avoid unsafe administration methods (your clinic protocols should reflect this).²

How we screen for safety

Before EBOO or systemic ozone therapies, we review:

• Medical history, current medications/supplements, and prior reactions

• Baseline risk factors and vitals

• When appropriate, lab screening (often including G6PD status)¹

Common short-term effects some people report

Depending on modality and individual response, some people report:

• Temporary fatigue/malaise, headache, or lightheadedness²

• Abdominal discomfort/nausea (more commonly reported with some insufflation routes)²

• Local irritation at an application site (method-dependent)²

When to contact us urgently

Contact us or seek urgent care if you develop:

• Severe shortness of breath, chest pain, fainting that doesn’t resolve

• Severe or worsening swelling/redness at an IV site

• Any symptom that feels severe or “not normal for you”

References 

1. MedMasters. Fundamental of IV Ozone. PDF (Contraindications list includes coagulation failure/bleeding risk, thrombocytopenia, recent MI, significant G6PD deficiency, uncontrolled hyperthyroidism, pregnancy-first trimester, alcohol intoxication). Published December 2023. Accessed February 4, 2026.
   
   
2. CAM Cancer Consortium (NAFKAM). Ozone therapy. Updated November 2025. Accessed February 4, 2026.